Drug interactions
Lovastatin + Sacubitril-valsartan
Severity: Minor
Lovastatin and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lovastatin is a possible OATP1B1 inhibitor and could modestly raise valsartan exposure, although statins are not established as meaningful inhibitors of this transporter. Any clinical effect is expected to be small.
What this interaction means in plain words
Lovastatin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lovastatin belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Theoretical inhibition of OATP1B1-mediated hepatic uptake of valsartan.
What to do
No dose adjustment is needed; routine blood pressure and potassium monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Lovastatin with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Lovastatin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lovastatin is a possible OATP1B1 inhibitor and could modestly raise valsartan exposure, although statins are not established as meaningful inhibitors of this transporter. Any clinical effect is expected to be small.
How serious is the interaction between Lovastatin and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; routine blood pressure and potassium monitoring is sufficient.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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