Drug interactions
Lovastatin + Sotorasib
Severity: Moderate
Lovastatin and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib induces CYP3A4 and can reduce exposure to CYP3A4 substrates such as lovastatin. Cholesterol-lowering efficacy may decline.
What this interaction means in plain words
Lovastatin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lovastatin belongs to Cardiovascular; Sotorasib belongs to Oncology.
Why it happens
Sotorasib induces CYP3A4, increasing lovastatin metabolism; P-gp effects are of minor relevance.
What to do
Monitor lipid levels and consider a statin not dependent on CYP3A4, such as rosuvastatin or pravastatin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Lovastatin with Sotorasib?
MediHelp rates the interaction as moderate. Lovastatin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib induces CYP3A4 and can reduce exposure to CYP3A4 substrates such as lovastatin. Cholesterol-lowering efficacy may decline.
How serious is the interaction between Lovastatin and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid levels and consider a statin not dependent on CYP3A4, such as rosuvastatin or pravastatin.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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