Drug interactions
Loxapine + Maprotiline
Severity: Moderate
Loxapine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and have anticholinergic activity, so combined use can cause marked drowsiness, hypotension and anticholinergic effects. Both also lower the seizure threshold, which increases the risk of convulsions, and loxapine can cause extrapyramidal effects.
What this interaction means in plain words
Loxapine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression, antimuscarinic effects and lowering of seizure threshold.
What to do
Use the lowest effective doses and monitor for sedation, orthostasis and seizures, especially in patients with epilepsy. Counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Maprotiline?
MediHelp rates the interaction as moderate. Loxapine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and have anticholinergic activity, so combined use can cause marked drowsiness, hypotension and anticholinergic effects. Both also lower the seizure threshold, which increases the risk of convulsions, and loxapine can cause extrapyramidal effects.
How serious is the interaction between Loxapine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, orthostasis and seizures, especially in patients with epilepsy. Counsel on driving.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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