Drug interactions
Loxapine + Metaxalone
Severity: Moderate
Loxapine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine is a sedating antipsychotic and may add to the drowsiness and psychomotor slowing from metaxalone. Inhaled loxapine can also cause bronchospasm and sedation, which merits attention.
What this interaction means in plain words
Loxapine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression.
What to do
Monitor for oversedation and impaired coordination, and counsel on driving. Adjust the dose of either drug if impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Metaxalone?
MediHelp rates the interaction as moderate. Loxapine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine is a sedating antipsychotic and may add to the drowsiness and psychomotor slowing from metaxalone. Inhaled loxapine can also cause bronchospasm and sedation, which merits attention.
How serious is the interaction between Loxapine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and impaired coordination, and counsel on driving. Adjust the dose of either drug if impairment develops.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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