Drug interactions
Loxapine + Methohexital
Severity: Moderate
Loxapine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine and methohexital both depress the central nervous system, so giving them together can deepen sedation and cause hypotension and respiratory depression. The risk is greatest around induction of anesthesia or procedural sedation.
What this interaction means in plain words
Loxapine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation by methohexital and dopamine, histamine and alpha-adrenergic blockade by loxapine.
What to do
Reduce the methohexital dose and titrate to effect, with continuous monitoring of respiration and blood pressure. Ensure airway support is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Methohexital
Frequently asked questions
Can I take Loxapine with Methohexital?
MediHelp rates the interaction as moderate. Loxapine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine and methohexital both depress the central nervous system, so giving them together can deepen sedation and cause hypotension and respiratory depression. The risk is greatest around induction of anesthesia or procedural sedation.
How serious is the interaction between Loxapine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the methohexital dose and titrate to effect, with continuous monitoring of respiration and blood pressure. Ensure airway support is available.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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