Drug interactions
Loxapine + Oxymorphone
Severity: Moderate
Loxapine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, so combining them can increase sedation, hypotension and respiratory depression. The effect is most important in elderly or debilitated patients.
What this interaction means in plain words
Loxapine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic sedative and antihistaminic effects.
What to do
Use reduced starting doses and titrate cautiously while monitoring sedation, blood pressure and respiratory status. Avoid inhaled loxapine in patients receiving high-dose opioids if respiratory function is compromised.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Oxymorphone?
MediHelp rates the interaction as moderate. Loxapine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, so combining them can increase sedation, hypotension and respiratory depression. The effect is most important in elderly or debilitated patients.
How serious is the interaction between Loxapine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced starting doses and titrate cautiously while monitoring sedation, blood pressure and respiratory status. Avoid inhaled loxapine in patients receiving high-dose opioids if respiratory function is compromised.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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