Drug interactions
Loxapine + Procarbazine
Severity: Moderate
Loxapine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitory activity and can interact with serotonergic and CNS-active drugs. Combined with an antipsychotic, additive sedation and, rarely, serotonergic toxicity or hypotension may occur. Documentation specific to loxapine is limited.
What this interaction means in plain words
Loxapine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition by procarbazine combined with additive CNS depression and receptor effects of loxapine.
What to do
Monitor for sedation, blood pressure changes, agitation, hyperthermia, and rigidity. Reduce the loxapine dose if excessive sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Loxapine with Procarbazine?
MediHelp rates the interaction as moderate. Loxapine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibitory activity and can interact with serotonergic and CNS-active drugs. Combined with an antipsychotic, additive sedation and, rarely, serotonergic toxicity or hypotension may occur. Documentation specific to loxapine is limited.
How serious is the interaction between Loxapine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, blood pressure changes, agitation, hyperthermia, and rigidity. Reduce the loxapine dose if excessive sedation develops.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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