Drug interactions
Loxapine + Secobarbital
Severity: Moderate
Loxapine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a barbiturate with the antipsychotic loxapine increases CNS and respiratory depression. Inhaled loxapine carries a risk of bronchospasm, and additional sedation can complicate recovery from it.
What this interaction means in plain words
Loxapine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; barbiturate enzyme induction may also reduce loxapine levels.
What to do
Monitor level of consciousness and respiratory status, and use the lowest effective doses. Watch for reduced antipsychotic effect if barbiturate therapy is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Secobarbital?
MediHelp rates the interaction as moderate. Loxapine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a barbiturate with the antipsychotic loxapine increases CNS and respiratory depression. Inhaled loxapine carries a risk of bronchospasm, and additional sedation can complicate recovery from it.
How serious is the interaction between Loxapine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness and respiratory status, and use the lowest effective doses. Watch for reduced antipsychotic effect if barbiturate therapy is prolonged.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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