Drug interactions
Loxapine + Tiotropium
Severity: Moderate
Loxapine and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has anticholinergic activity that may add to the antimuscarinic effect of tiotropium. This can increase dry mouth, constipation, urinary retention, blurred vision and the risk of angle-closure glaucoma, especially in older patients.
What this interaction means in plain words
Loxapine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Tiotropium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects; systemic exposure to inhaled tiotropium is low, which limits the interaction.
What to do
Monitor for anticholinergic adverse effects such as urinary retention, constipation and eye pain. Review the need for both drugs in older patients or those with glaucoma or prostatic hypertrophy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Tiotropium?
MediHelp rates the interaction as moderate. Loxapine and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has anticholinergic activity that may add to the antimuscarinic effect of tiotropium. This can increase dry mouth, constipation, urinary retention, blurred vision and the risk of angle-closure glaucoma, especially in older patients.
How serious is the interaction between Loxapine and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary retention, constipation and eye pain. Review the need for both drugs in older patients or those with glaucoma or prostatic hypertrophy.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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