Drug interactions
Loxapine + Tranylcypromine
Severity: Moderate
Loxapine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an irreversible MAO inhibitor with an antipsychotic may add serotonergic and dopamine-blocking effects. This raises concern for serotonin toxicity and neuroleptic malignant syndrome, and loxapine can also add hypotension and sedation.
What this interaction means in plain words
Loxapine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loxapine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects: MAO inhibition raises monoamine levels while loxapine blocks dopamine and serotonin receptors.
What to do
Use only when clearly needed, starting with low loxapine doses. Monitor for hyperthermia, rigidity, autonomic instability, agitation, clonus and orthostatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Loxapine with Tranylcypromine?
MediHelp rates the interaction as moderate. Loxapine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an irreversible MAO inhibitor with an antipsychotic may add serotonergic and dopamine-blocking effects. This raises concern for serotonin toxicity and neuroleptic malignant syndrome, and loxapine can also add hypotension and sedation.
How serious is the interaction between Loxapine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when clearly needed, starting with low loxapine doses. Monitor for hyperthermia, rigidity, autonomic instability, agitation, clonus and orthostatic hypotension.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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