Drug interactions
Loxapine inhaled + Mirtazapine
Severity: Moderate
Loxapine inhaled and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine can cause sedation and bronchospasm, and mirtazapine adds to CNS depression. Combined use may increase drowsiness and impaired alertness.
What this interaction means in plain words
Loxapine inhaled and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects from antipsychotic and antihistaminic activity.
What to do
Monitor for excessive sedation after loxapine dosing and observe patients as required by the product's restricted program. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Loxapine inhaled with Mirtazapine?
MediHelp rates the interaction as moderate. Loxapine inhaled and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine can cause sedation and bronchospasm, and mirtazapine adds to CNS depression. Combined use may increase drowsiness and impaired alertness.
How serious is the interaction between Loxapine inhaled and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation after loxapine dosing and observe patients as required by the product's restricted program. Avoid alcohol and other sedatives.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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