Drug interactions
Loxapine inhaled + Tramadol
Severity: Moderate
Loxapine inhaled and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine causes sedation and can cause bronchospasm, and tramadol adds CNS and respiratory depression. Together they may produce excessive sedation.
What this interaction means in plain words
Loxapine inhaled and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and respiratory status after inhaled loxapine in patients taking tramadol, and reduce doses if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Loxapine inhaled with Tramadol?
MediHelp rates the interaction as moderate. Loxapine inhaled and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine causes sedation and can cause bronchospasm, and tramadol adds CNS and respiratory depression. Together they may produce excessive sedation.
How serious is the interaction between Loxapine inhaled and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after inhaled loxapine in patients taking tramadol, and reduce doses if oversedation occurs.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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