Drug interactions
Loxapine inhaled + Trazodone
Severity: Moderate
Loxapine inhaled and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine causes sedation and can cause bronchospasm, and trazodone adds further CNS depression and hypotension. The combination may lead to marked drowsiness and dizziness.
What this interaction means in plain words
Loxapine inhaled and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Monitor patients for sedation and blood pressure after loxapine dosing. Ensure the patient is observed in a supervised setting as required by the loxapine program.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Loxapine inhaled with Trazodone?
MediHelp rates the interaction as moderate. Loxapine inhaled and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine causes sedation and can cause bronchospasm, and trazodone adds further CNS depression and hypotension. The combination may lead to marked drowsiness and dizziness.
How serious is the interaction between Loxapine inhaled and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for sedation and blood pressure after loxapine dosing. Ensure the patient is observed in a supervised setting as required by the loxapine program.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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