Drug interactions
Lsd + Rizatriptan
Severity: Moderate
Lsd and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a potent serotonin receptor agonist, mainly at 5-HT2A. Combining it with a triptan may add to serotonergic and vasoconstrictive effects. Evidence is limited to theory and sparse reports.
What this interaction means in plain words
Lsd and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonin receptor agonism, with possible additive vasoconstriction.
What to do
Advise against taking triptans around recreational LSD use. If exposure occurs, monitor for serotonin toxicity and hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lsd and Rizatriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Lsd with Rizatriptan?
MediHelp rates the interaction as moderate. Lsd and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD is a potent serotonin receptor agonist, mainly at 5-HT2A. Combining it with a triptan may add to serotonergic and vasoconstrictive effects. Evidence is limited to theory and sparse reports.
How serious is the interaction between Lsd and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against taking triptans around recreational LSD use. If exposure occurs, monitor for serotonin toxicity and hypertension.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
