Drug interactions
Lsd + Trazodone
Severity: Moderate
Lsd and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD acts at serotonin receptors, and combination with serotonergic drugs may lead to unpredictable effects including serotonin toxicity. Serotonergic antidepressants may also blunt or alter LSD effects.
What this interaction means in plain words
Lsd and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Overlapping serotonergic activity at 5-HT receptors and altered receptor sensitivity.
What to do
Advise against recreational LSD use during trazodone therapy. Monitor for serotonin syndrome if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Lsd with Trazodone?
MediHelp rates the interaction as moderate. Lsd and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD acts at serotonin receptors, and combination with serotonergic drugs may lead to unpredictable effects including serotonin toxicity. Serotonergic antidepressants may also blunt or alter LSD effects.
How serious is the interaction between Lsd and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against recreational LSD use during trazodone therapy. Monitor for serotonin syndrome if exposure occurs.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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