Drug interactions
Lsd + Trimipramine
Severity: Moderate
Lsd and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a serotonin receptor agonist, and tricyclic antidepressants alter its subjective effects, sometimes intensifying them. The combination may add to serotonergic toxicity and adverse psychiatric reactions, but data are limited.
What this interaction means in plain words
Lsd and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Serotonin receptor agonism by LSD combined with serotonergic modulation by trimipramine; the exact mechanism is not firmly established.
What to do
Advise against use of LSD during trimipramine treatment. If exposure occurs, observe for agitation, hyperthermia, tachycardia, and neuromuscular signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Lsd with Trimipramine?
MediHelp rates the interaction as moderate. Lsd and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD is a serotonin receptor agonist, and tricyclic antidepressants alter its subjective effects, sometimes intensifying them. The combination may add to serotonergic toxicity and adverse psychiatric reactions, but data are limited.
How serious is the interaction between Lsd and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against use of LSD during trimipramine treatment. If exposure occurs, observe for agitation, hyperthermia, tachycardia, and neuromuscular signs.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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