Drug interactions
Lumacaftor / ivacaftor + Modafinil
Severity: Moderate
Lumacaftor / ivacaftor and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may lower modafinil concentrations, reducing efficacy. Modafinil is also partly CYP2C19-dependent, and lumacaftor/ivacaftor have mixed inducing and inhibiting effects on CYP2C19, so net changes are unpredictable.
What this interaction means in plain words
Lumacaftor / ivacaftor and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induction of CYP3A4 (and variable CYP2C19 effects) alters modafinil clearance.
What to do
Monitor for reduced wakefulness response to modafinil and titrate the dose to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Modafinil?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may lower modafinil concentrations, reducing efficacy. Modafinil is also partly CYP2C19-dependent, and lumacaftor/ivacaftor have mixed inducing and inhibiting effects on CYP2C19, so net changes are unpredictable.
How serious is the interaction between Lumacaftor / ivacaftor and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced wakefulness response to modafinil and titrate the dose to effect.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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