Drug interactions
Lumacaftor / ivacaftor + Trimipramine
Severity: Moderate
Lumacaftor / ivacaftor and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor induces and ivacaftor may inhibit CYP2C19, which contributes to trimipramine metabolism, so the net effect on levels is unpredictable. Trimipramine exposure may be reduced or fluctuate, affecting efficacy or tolerability.
What this interaction means in plain words
Lumacaftor / ivacaftor and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Net CYP induction (lumacaftor), with possible inhibition (ivacaftor), altering CYP2C19 and CYP3A4 metabolism of trimipramine.
What to do
Monitor antidepressant response and tricyclic adverse effects, and consider plasma level monitoring. Adjust the trimipramine dose as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Lumacaftor / ivacaftor with Trimipramine?
MediHelp rates the interaction as moderate. Lumacaftor / ivacaftor and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor induces and ivacaftor may inhibit CYP2C19, which contributes to trimipramine metabolism, so the net effect on levels is unpredictable. Trimipramine exposure may be reduced or fluctuate, affecting efficacy or tolerability.
How serious is the interaction between Lumacaftor / ivacaftor and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and tricyclic adverse effects, and consider plasma level monitoring. Adjust the trimipramine dose as indicated.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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