Drug interactions
Lumateperone + Ribociclib
Severity: Moderate
Lumateperone and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib can increase lumateperone exposure, intensifying sedation, orthostatic hypotension and other adverse effects.
What this interaction means in plain words
Lumateperone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lumateperone belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, decreasing lumateperone clearance.
What to do
Reduce lumateperone to 21 mg daily with moderate CYP3A inhibitors and monitor for sedation and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Lumateperone
Frequently asked questions
Can I take Lumateperone with Ribociclib?
MediHelp rates the interaction as moderate. Lumateperone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib can increase lumateperone exposure, intensifying sedation, orthostatic hypotension and other adverse effects.
How serious is the interaction between Lumateperone and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to 21 mg daily with moderate CYP3A inhibitors and monitor for sedation and hypotension.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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