Drug interactions
Lumefantrine + Methamphetamine
Severity: Moderate
Lumefantrine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a CYP2D6 inhibitor and methamphetamine is partly metabolised by CYP2D6, so exposure to methamphetamine could rise. This may increase sympathomimetic effects such as hypertension, tachycardia and agitation. The clinical effect is modest and is likely to be limited for a short antimalarial course.
What this interaction means in plain words
Lumefantrine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumefantrine inhibits CYP2D6, reducing the metabolism of methamphetamine.
What to do
Monitor blood pressure, heart rate and symptoms of stimulant excess during the antimalarial course. Reduce the methamphetamine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lumefantrine with Methamphetamine?
MediHelp rates the interaction as moderate. Lumefantrine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is a CYP2D6 inhibitor and methamphetamine is partly metabolised by CYP2D6, so exposure to methamphetamine could rise. This may increase sympathomimetic effects such as hypertension, tachycardia and agitation. The clinical effect is modest and is likely to be limited for a short antimalarial course.
How serious is the interaction between Lumefantrine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and symptoms of stimulant excess during the antimalarial course. Reduce the methamphetamine dose if adverse effects appear.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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