Drug interactions
Lumefantrine + Oxycodone
Severity: Minor
Lumefantrine and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine has weak CYP2D6 inhibitory activity, which would only slightly alter oxycodone metabolism to oxymorphone. Since oxycodone itself is the main active moiety, no meaningful clinical effect is expected.
What this interaction means in plain words
Lumefantrine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP2D6 inhibition may marginally reduce oxymorphone formation.
What to do
No dose adjustment is needed; monitor analgesic response as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Lumefantrine with Oxycodone?
MediHelp rates the interaction as minor. Lumefantrine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine has weak CYP2D6 inhibitory activity, which would only slightly alter oxycodone metabolism to oxymorphone. Since oxycodone itself is the main active moiety, no meaningful clinical effect is expected.
How serious is the interaction between Lumefantrine and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor analgesic response as usual.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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