Drug interactions
Lumefantrine + Ranolazine
Severity: Moderate
Lumefantrine and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a weak CYP3A4 inducer in practice and prolongs the QT interval. Any reduction in ranolazine exposure is likely small, but QT effects may be additive.
What this interaction means in plain words
Lumefantrine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with possible weak CYP3A4 induction.
What to do
Monitor ECG QTc and electrolytes during treatment. Check angina control after the course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Lumefantrine with Ranolazine?
MediHelp rates the interaction as moderate. Lumefantrine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is a weak CYP3A4 inducer in practice and prolongs the QT interval. Any reduction in ranolazine exposure is likely small, but QT effects may be additive.
How serious is the interaction between Lumefantrine and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG QTc and electrolytes during treatment. Check angina control after the course.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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