Drug interactions
Lumefantrine + Temsirolimus
Severity: Minor
Lumefantrine and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is reported to have weak CYP3A4 induction potential, which could lower temsirolimus and sirolimus exposure. The effect is likely small and short-lived given the brief antimalarial course.
What this interaction means in plain words
Lumefantrine and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak induction of CYP3A4 by lumefantrine increasing temsirolimus metabolism.
What to do
No dose adjustment is usually needed; monitor clinical response to temsirolimus during and shortly after the antimalarial course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Lumefantrine with Temsirolimus?
MediHelp rates the interaction as minor. Lumefantrine and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is reported to have weak CYP3A4 induction potential, which could lower temsirolimus and sirolimus exposure. The effect is likely small and short-lived given the brief antimalarial course.
How serious is the interaction between Lumefantrine and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor clinical response to temsirolimus during and shortly after the antimalarial course.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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