Drug interactions
Lumefantrine + Tramadol
Severity: Moderate
Lumefantrine and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6, which could reduce formation of tramadol's active opioid metabolite O-desmethyltramadol, lowering analgesia while raising parent drug levels with more serotonergic effects.
What this interaction means in plain words
Lumefantrine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by lumefantrine reducing conversion of tramadol to O-desmethyltramadol.
What to do
Monitor pain control and serotonergic or seizure adverse effects during the antimalarial course; consider an alternative analgesic if pain control fails.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Lumefantrine with Tramadol?
MediHelp rates the interaction as moderate. Lumefantrine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine inhibits CYP2D6, which could reduce formation of tramadol's active opioid metabolite O-desmethyltramadol, lowering analgesia while raising parent drug levels with more serotonergic effects.
How serious is the interaction between Lumefantrine and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and serotonergic or seizure adverse effects during the antimalarial course; consider an alternative analgesic if pain control fails.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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