Drug interactions
Lurasidone + Methadone
Severity: Moderate
Lurasidone and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and combined use may increase CNS depression. Lurasidone has minimal QT effect, but methadone may add to orthostasis and psychomotor impairment.
What this interaction means in plain words
Lurasidone and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; no established pharmacokinetic interaction.
What to do
Monitor for excess sedation, dizziness and orthostatic hypotension, especially when starting or increasing either drug. Advise the patient about driving and other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Methadone?
MediHelp rates the interaction as moderate. Lurasidone and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and combined use may increase CNS depression. Lurasidone has minimal QT effect, but methadone may add to orthostasis and psychomotor impairment.
How serious is the interaction between Lurasidone and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, dizziness and orthostatic hypotension, especially when starting or increasing either drug. Advise the patient about driving and other hazardous activities.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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