Drug interactions
Lurasidone + Methyldopa
Severity: Moderate
Lurasidone and Methyldopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-1 blocking activity and can cause orthostatic hypotension, which may add to the blood pressure lowering of methyldopa. Dizziness and falls are the main concern.
What this interaction means in plain words
Lurasidone and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Methyldopa belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic antagonism and central sympatholytic action.
What to do
Monitor blood pressure, including orthostatic readings, when lurasidone is started or titrated. Reduce the methyldopa dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Methyldopa?
MediHelp rates the interaction as moderate. Lurasidone and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-1 blocking activity and can cause orthostatic hypotension, which may add to the blood pressure lowering of methyldopa. Dizziness and falls are the main concern.
How serious is the interaction between Lurasidone and Methyldopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including orthostatic readings, when lurasidone is started or titrated. Reduce the methyldopa dose if symptomatic hypotension develops.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
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