Drug interactions
Lurasidone + Nilotinib
Severity: Moderate
Lurasidone and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib can raise lurasidone exposure through inhibition of CYP3A4, increasing the risk of lurasidone adverse effects such as akathisia, sedation and extrapyramidal symptoms. Nilotinib also prolongs the QT interval, which adds to the concern.
What this interaction means in plain words
Lurasidone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Nilotinib is a weak to moderate CYP3A4 inhibitor, reducing the metabolism of lurasidone, a CYP3A4 substrate, with additive QT effects possible.
What to do
Lower the lurasidone starting dose and cap the daily dose as recommended for moderate CYP3A4 inhibitors. Monitor ECG and for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Lurasidone with Nilotinib?
MediHelp rates the interaction as moderate. Lurasidone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib can raise lurasidone exposure through inhibition of CYP3A4, increasing the risk of lurasidone adverse effects such as akathisia, sedation and extrapyramidal symptoms. Nilotinib also prolongs the QT interval, which adds to the concern.
How serious is the interaction between Lurasidone and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower the lurasidone starting dose and cap the daily dose as recommended for moderate CYP3A4 inhibitors. Monitor ECG and for adverse effects.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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