Drug interactions
Lurasidone + Nortriptyline
Severity: Minor
Lurasidone and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone and nortriptyline both act on the CNS and may cause additive drowsiness, dizziness and orthostatic hypotension. Clinically significant harm is usually modest.
What this interaction means in plain words
Lurasidone and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS and hypotensive effects through pharmacodynamic mechanisms.
What to do
Monitor sedation and orthostatic blood pressure when starting or adjusting either drug. Counsel patients on rising slowly and driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Nortriptyline?
MediHelp rates the interaction as minor. Lurasidone and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lurasidone and nortriptyline both act on the CNS and may cause additive drowsiness, dizziness and orthostatic hypotension. Clinically significant harm is usually modest.
How serious is the interaction between Lurasidone and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure when starting or adjusting either drug. Counsel patients on rising slowly and driving.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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