Drug interactions
Lurasidone + Oxazepam
Severity: Moderate
Lurasidone and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with an atypical antipsychotic can produce additive sedation, dizziness and psychomotor impairment. Orthostatic hypotension and falls may also be more likely, particularly in older adults.
What this interaction means in plain words
Lurasidone and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through GABA-A potentiation by oxazepam and histamine, alpha-adrenergic and serotonergic receptor antagonism by lurasidone.
What to do
Start at the lower end of dosing and monitor for sedation, orthostatic hypotension and impaired psychomotor performance. Counsel patients to avoid driving and alcohol until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Oxazepam?
MediHelp rates the interaction as moderate. Lurasidone and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a benzodiazepine with an atypical antipsychotic can produce additive sedation, dizziness and psychomotor impairment. Orthostatic hypotension and falls may also be more likely, particularly in older adults.
How serious is the interaction between Lurasidone and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at the lower end of dosing and monitor for sedation, orthostatic hypotension and impaired psychomotor performance. Counsel patients to avoid driving and alcohol until the response is known.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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