Drug interactions
Lurasidone + Oxcarbazepine
Severity: Major
Lurasidone and Oxcarbazepine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak to moderate CYP3A4 inducer that may lower lurasidone concentrations. Reduced exposure could lead to loss of antipsychotic effect and relapse.
What this interaction means in plain words
Lurasidone and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurasidone belongs to Central Nervous System; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by oxcarbazepine increasing lurasidone metabolism.
What to do
Avoid if possible; otherwise monitor for loss of efficacy and consider a lurasidone dose increase guided by clinical response. Reassess the dose when oxcarbazepine is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Lurasidone with Oxcarbazepine?
MediHelp rates the interaction as major. Lurasidone and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine is a weak to moderate CYP3A4 inducer that may lower lurasidone concentrations. Reduced exposure could lead to loss of antipsychotic effect and relapse.
How serious is the interaction between Lurasidone and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor for loss of efficacy and consider a lurasidone dose increase guided by clinical response. Reassess the dose when oxcarbazepine is stopped.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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