Drug interactions
Lurasidone + Paroxetine
Severity: Minor
Lurasidone and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine has little effect on lurasidone, which is cleared by CYP3A4, though additive CNS effects and rare serotonergic or neuroleptic malignant syndrome events are possible. Clinically significant interaction is uncommon.
What this interaction means in plain words
Lurasidone and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
Mainly additive pharmacodynamic CNS and serotonergic effects; no important pharmacokinetic interaction is expected.
What to do
Monitor for sedation, akathisia and signs of serotonin syndrome when starting or adjusting either drug. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Paroxetine?
MediHelp rates the interaction as minor. Lurasidone and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paroxetine has little effect on lurasidone, which is cleared by CYP3A4, though additive CNS effects and rare serotonergic or neuroleptic malignant syndrome events are possible. Clinically significant interaction is uncommon.
How serious is the interaction between Lurasidone and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, akathisia and signs of serotonin syndrome when starting or adjusting either drug. No routine dose change is needed.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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