Drug interactions
Lurasidone + Phenelzine
Severity: Moderate
Lurasidone and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an irreversible MAO inhibitor with lurasidone may add to hypotension and sedation, and rarely the serotonergic and dopamine-blocking effects of the two drugs could contribute to serotonin toxicity or neuroleptic malignant syndrome. The label of lurasidone does not list a formal contraindication with MAOIs, but the overlap in adverse effects is clinically relevant.
What this interaction means in plain words
Lurasidone and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects: MAO inhibition raises monoamine levels while lurasidone adds alpha-adrenergic, serotonergic and dopaminergic receptor effects and CNS depression.
What to do
Monitor blood pressure, orthostatic symptoms and sedation, particularly during initiation and dose changes. Watch for fever, rigidity, agitation or autonomic instability and reduce doses or stop one agent if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Phenelzine?
MediHelp rates the interaction as moderate. Lurasidone and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an irreversible MAO inhibitor with lurasidone may add to hypotension and sedation, and rarely the serotonergic and dopamine-blocking effects of the two drugs could contribute to serotonin toxicity or neuroleptic malignant syndrome. The label of lurasidone does not list a formal contraindication with MAOIs, but the overlap in adverse effects is clinically relevant.
How serious is the interaction between Lurasidone and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, orthostatic symptoms and sedation, particularly during initiation and dose changes. Watch for fever, rigidity, agitation or autonomic instability and reduce doses or stop one agent if they appear.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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