Drug interactions
Lurasidone + Pioglitazone
Severity: Minor
Lurasidone and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can raise blood glucose and may counteract antidiabetic therapy. Lurasidone has relatively low metabolic liability but diabetic patients may still need closer observation.
What this interaction means in plain words
Lurasidone and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Pioglitazone belongs to Endocrine.
Why it happens
Antipsychotic-associated insulin resistance and impaired glucose regulation oppose the insulin-sensitizing effect.
What to do
Monitor blood glucose and HbA1c after starting or changing lurasidone and adjust diabetes therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Pioglitazone
Frequently asked questions
Can I take Lurasidone with Pioglitazone?
MediHelp rates the interaction as minor. Lurasidone and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics can raise blood glucose and may counteract antidiabetic therapy. Lurasidone has relatively low metabolic liability but diabetic patients may still need closer observation.
How serious is the interaction between Lurasidone and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing lurasidone and adjust diabetes therapy if needed.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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