Drug interactions
Lurasidone + Rasagiline
Severity: Moderate
Lurasidone and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause orthostatic hypotension through alpha-1 adrenergic blockade, and rasagiline may also lower blood pressure, particularly on standing. Used together, dizziness, syncope and falls may be more likely, especially in older patients.
What this interaction means in plain words
Lurasidone and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 blockade by lurasidone and the orthostatic effects of MAO-B inhibition.
What to do
Monitor supine and standing blood pressure when starting or adjusting either drug and counsel patients to rise slowly. Reduce doses or adjust antihypertensives if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Lurasidone with Rasagiline?
MediHelp rates the interaction as moderate. Lurasidone and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause orthostatic hypotension through alpha-1 adrenergic blockade, and rasagiline may also lower blood pressure, particularly on standing. Used together, dizziness, syncope and falls may be more likely, especially in older patients.
How serious is the interaction between Lurasidone and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting or adjusting either drug and counsel patients to rise slowly. Reduce doses or adjust antihypertensives if symptomatic hypotension occurs.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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