Drug interactions
Lurasidone + Repaglinide
Severity: Moderate
Lurasidone and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can raise blood glucose in some patients, though its metabolic liability is relatively low among atypical antipsychotics. This may reduce the glucose-lowering effect of repaglinide and worsen diabetes control.
What this interaction means in plain words
Lurasidone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: antipsychotic-associated insulin resistance and impaired glucose regulation oppose the insulin secretagogue effect.
What to do
Check fasting glucose and HbA1c at baseline and periodically after starting lurasidone. Adjust the repaglinide dose if glycemic control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Lurasidone with Repaglinide?
MediHelp rates the interaction as moderate. Lurasidone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can raise blood glucose in some patients, though its metabolic liability is relatively low among atypical antipsychotics. This may reduce the glucose-lowering effect of repaglinide and worsen diabetes control.
How serious is the interaction between Lurasidone and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose and HbA1c at baseline and periodically after starting lurasidone. Adjust the repaglinide dose if glycemic control worsens.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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