Drug interactions
Lurasidone + Ropinirole
Severity: Moderate
Lurasidone and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone blocks dopamine D2 receptors while ropinirole is a D2/D3 agonist, so each opposes the other's action. Parkinsonian motor symptoms may worsen and psychotic symptoms may be aggravated by the dopamine agonist.
What this interaction means in plain words
Lurasidone and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Ropinirole belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Monitor motor function and psychiatric symptoms closely. In Parkinson's disease psychosis prefer an agent with minimal D2 blockade such as quetiapine or clozapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Lurasidone with Ropinirole?
MediHelp rates the interaction as moderate. Lurasidone and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone blocks dopamine D2 receptors while ropinirole is a D2/D3 agonist, so each opposes the other's action. Parkinsonian motor symptoms may worsen and psychotic symptoms may be aggravated by the dopamine agonist.
How serious is the interaction between Lurasidone and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor function and psychiatric symptoms closely. In Parkinson's disease psychosis prefer an agent with minimal D2 blockade such as quetiapine or clozapine.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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