Drug interactions
Lurasidone + Sacubitril-valsartan
Severity: Moderate
Lurasidone and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause orthostatic hypotension through alpha-1 adrenergic blockade. Added to the blood pressure lowering of sacubitril-valsartan, this may cause symptomatic hypotension, dizziness or falls, especially at initiation or after dose increases.
What this interaction means in plain words
Lurasidone and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 blockade (lurasidone) and angiotensin receptor blockade plus neprilysin inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the dose of the antihypertensive if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Lurasidone and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause orthostatic hypotension through alpha-1 adrenergic blockade. Added to the blood pressure lowering of sacubitril-valsartan, this may cause symptomatic hypotension, dizziness or falls, especially at initiation or after dose increases.
How serious is the interaction between Lurasidone and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the dose of the antihypertensive if symptomatic hypotension develops.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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