Drug interactions
Lurasidone + Safinamide
Severity: Major
Lurasidone and Safinamide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone blocks dopamine D2 receptors and can oppose the dopaminergic benefit of safinamide in Parkinson disease. This may worsen motor symptoms.
What this interaction means in plain words
Lurasidone and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurasidone belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: D2 receptor blockade by lurasidone opposes the dopaminergic effect of safinamide.
What to do
Avoid in Parkinson disease where possible; if an antipsychotic is needed, prefer quetiapine or clozapine. Monitor motor function closely if the combination is used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Lurasidone with Safinamide?
MediHelp rates the interaction as major. Lurasidone and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lurasidone blocks dopamine D2 receptors and can oppose the dopaminergic benefit of safinamide in Parkinson disease. This may worsen motor symptoms.
How serious is the interaction between Lurasidone and Safinamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in Parkinson disease where possible; if an antipsychotic is needed, prefer quetiapine or clozapine. Monitor motor function closely if the combination is used.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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