Drug interactions
Lurasidone + Selegiline
Severity: Moderate
Lurasidone and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, and the dopaminergic and serotonergic activity of selegiline may oppose lurasidone's D2 blockade. Rare reports suggest a risk of serotonin toxicity or neuroleptic malignant syndrome with combined serotonergic and antidopaminergic agents, and parkinsonism may worsen.
What this interaction means in plain words
Lurasidone and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at dopamine receptors plus additive hypotensive and possible serotonergic effects.
What to do
Monitor blood pressure, motor symptoms, mental status and temperature, especially at initiation or dose changes. Avoid higher selegiline doses that lose MAO-B selectivity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Lurasidone with Selegiline?
MediHelp rates the interaction as moderate. Lurasidone and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure, and the dopaminergic and serotonergic activity of selegiline may oppose lurasidone's D2 blockade. Rare reports suggest a risk of serotonin toxicity or neuroleptic malignant syndrome with combined serotonergic and antidopaminergic agents, and parkinsonism may worsen.
How serious is the interaction between Lurasidone and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, motor symptoms, mental status and temperature, especially at initiation or dose changes. Avoid higher selegiline doses that lose MAO-B selectivity.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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