Drug interactions
Lurasidone + Spironolactone
Severity: Minor
Lurasidone and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-adrenergic blocking activity that may cause orthostatic hypotension, which can add to the blood pressure lowering of spironolactone. Patients may experience dizziness or falls.
What this interaction means in plain words
Lurasidone and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Spironolactone belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-1 blockade by lurasidone and diuretic-induced volume reduction.
What to do
Monitor blood pressure and orthostatic symptoms, especially when starting or titrating lurasidone. Adjust antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Spironolactone?
MediHelp rates the interaction as minor. Lurasidone and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lurasidone has alpha-adrenergic blocking activity that may cause orthostatic hypotension, which can add to the blood pressure lowering of spironolactone. Patients may experience dizziness or falls.
How serious is the interaction between Lurasidone and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially when starting or titrating lurasidone. Adjust antihypertensive dose if hypotension occurs.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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