Drug interactions
Lurasidone + Tamoxifen
Severity: Minor
Lurasidone and Tamoxifen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamoxifen is a weak CYP3A4 inhibitor and lurasidone is a CYP3A4 substrate, so lurasidone exposure could rise modestly. Increased sedation, akathisia or parkinsonism could result, though a significant effect is not well documented.
What this interaction means in plain words
Lurasidone and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurasidone belongs to Central Nervous System; Tamoxifen belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4-mediated lurasidone metabolism by tamoxifen.
What to do
No dose change is usually needed. Monitor for lurasidone adverse effects such as akathisia and somnolence.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Lurasidone with Tamoxifen?
MediHelp rates the interaction as minor. Lurasidone and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tamoxifen is a weak CYP3A4 inhibitor and lurasidone is a CYP3A4 substrate, so lurasidone exposure could rise modestly. Increased sedation, akathisia or parkinsonism could result, though a significant effect is not well documented.
How serious is the interaction between Lurasidone and Tamoxifen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for lurasidone adverse effects such as akathisia and somnolence.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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