Drug interactions
Lurasidone + Timolol
Severity: Moderate
Lurasidone and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-1 blocking activity that can cause orthostatic hypotension, and this may add to the blood pressure lowering effect of timolol. Dizziness, syncope and falls are the main concerns.
What this interaction means in plain words
Lurasidone and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from antipsychotic alpha-adrenergic blockade and beta-blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating lurasidone. Reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Timolol?
MediHelp rates the interaction as moderate. Lurasidone and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-1 blocking activity that can cause orthostatic hypotension, and this may add to the blood pressure lowering effect of timolol. Dizziness, syncope and falls are the main concerns.
How serious is the interaction between Lurasidone and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating lurasidone. Reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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