Drug interactions
Lurasidone + Trandolapril
Severity: Moderate
Lurasidone and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension. Combined with an ACE inhibitor, blood pressure lowering may be additive, with dizziness or syncope.
What this interaction means in plain words
Lurasidone and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Trandolapril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-1 blockade and inhibition of the renin-angiotensin system.
What to do
Monitor blood pressure and orthostatic symptoms, especially during dose titration. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Trandolapril?
MediHelp rates the interaction as moderate. Lurasidone and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension. Combined with an ACE inhibitor, blood pressure lowering may be additive, with dizziness or syncope.
How serious is the interaction between Lurasidone and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially during dose titration. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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