Drug interactions
Lurasidone + Zuranolone
Severity: Moderate
Lurasidone and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes sedation and psychomotor impairment, and lurasidone adds to these effects. The combination may produce excessive drowsiness and impair driving ability.
What this interaction means in plain words
Lurasidone and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression, with zuranolone enhancing GABA-A receptor activity.
What to do
Counsel patients to avoid driving and hazardous activities, and reduce the zuranolone dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Lurasidone with Zuranolone?
MediHelp rates the interaction as moderate. Lurasidone and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes sedation and psychomotor impairment, and lurasidone adds to these effects. The combination may produce excessive drowsiness and impair driving ability.
How serious is the interaction between Lurasidone and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and hazardous activities, and reduce the zuranolone dose if sedation is excessive.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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