Drug interactions
Lurbinectedin + Mifepristone
Severity: Major
Lurbinectedin and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, the main route of lurbinectedin metabolism, so lurbinectedin exposure may rise. This raises the risk of myelosuppression and hepatotoxicity.
What this interaction means in plain words
Lurbinectedin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurbinectedin belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lurbinectedin by mifepristone.
What to do
Avoid the combination. If unavoidable, reduce the lurbinectedin dose by 50% and monitor blood counts and liver tests.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Lurbinectedin with Mifepristone?
MediHelp rates the interaction as major. Lurbinectedin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone inhibits CYP3A4, the main route of lurbinectedin metabolism, so lurbinectedin exposure may rise. This raises the risk of myelosuppression and hepatotoxicity.
How serious is the interaction between Lurbinectedin and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If unavoidable, reduce the lurbinectedin dose by 50% and monitor blood counts and liver tests.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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