Drug interactions
Lurbinectedin + Rifampicin
Severity: Major
Lurbinectedin and Rifampicin: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin lowers lurbinectedin exposure, which may reduce its antitumor efficacy.
What this interaction means in plain words
Lurbinectedin and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurbinectedin belongs to Oncology; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin strongly induces CYP3A4, increasing lurbinectedin metabolism.
What to do
Avoid strong CYP3A inducers and select an alternative agent. Use an alternative antimycobacterial if clinically possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lurbinectedin
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Lurbinectedin with Rifampicin?
MediHelp rates the interaction as major. Lurbinectedin and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin lowers lurbinectedin exposure, which may reduce its antitumor efficacy.
How serious is the interaction between Lurbinectedin and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A inducers and select an alternative agent. Use an alternative antimycobacterial if clinically possible.
What other medicines interact with Lurbinectedin?
MediHelp also lists interactions of Lurbinectedin with, for example, Amiodarone, Amobarbital, Apalutamide. The full list is on the Lurbinectedin page.
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