Drug interactions
Lurbinectedin + Sertraline
Severity: Minor
Lurbinectedin and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurbinectedin is metabolised mainly by CYP3A4, and inhibitors can raise its exposure and increase myelosuppression and hepatotoxicity. Sertraline is only a weak CYP3A4 inhibitor, so the effect is likely small.
What this interaction means in plain words
Lurbinectedin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lurbinectedin belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated lurbinectedin metabolism by sertraline.
What to do
No dose change is usually required; monitor blood counts and liver enzymes as per routine lurbinectedin care. Avoid adding stronger CYP3A4 inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Lurbinectedin with Sertraline?
MediHelp rates the interaction as minor. Lurbinectedin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lurbinectedin is metabolised mainly by CYP3A4, and inhibitors can raise its exposure and increase myelosuppression and hepatotoxicity. Sertraline is only a weak CYP3A4 inhibitor, so the effect is likely small.
How serious is the interaction between Lurbinectedin and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor blood counts and liver enzymes as per routine lurbinectedin care. Avoid adding stronger CYP3A4 inhibitors.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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