Drug interactions
Lurbinectedin + Verapamil
Severity: Major
Lurbinectedin and Verapamil: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase lurbinectedin exposure through CYP3A4 inhibition. This raises the risk of myelosuppression and hepatotoxicity.
What this interaction means in plain words
Lurbinectedin and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lurbinectedin belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, the main enzyme metabolizing lurbinectedin.
What to do
Avoid if possible; if needed, consider reducing lurbinectedin dose per labeling and monitor blood counts and liver tests.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Lurbinectedin with Verapamil?
MediHelp rates the interaction as major. Lurbinectedin and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Verapamil may increase lurbinectedin exposure through CYP3A4 inhibition. This raises the risk of myelosuppression and hepatotoxicity.
How serious is the interaction between Lurbinectedin and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, consider reducing lurbinectedin dose per labeling and monitor blood counts and liver tests.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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