Drug interactions
Macimorelin + Mecasermin
Severity: Moderate
Macimorelin and Mecasermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin is used as a diagnostic stimulant of growth hormone release, and its result depends on an unblunted GH response. Mecasermin is recombinant IGF-1, which exerts negative feedback on pituitary GH secretion, so it may suppress the response and cause a falsely abnormal result.
What this interaction means in plain words
Macimorelin and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Mecasermin belongs to Endocrine.
Why it happens
Exogenous IGF-1 suppresses pituitary GH secretion through negative feedback, which may blunt the macimorelin-stimulated GH peak.
What to do
Hold mecasermin for an adequate washout period before macimorelin testing, following the macimorelin labeling, and interpret results cautiously if it was not stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mecasermin
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Mecasermin?
MediHelp rates the interaction as moderate. Macimorelin and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin is used as a diagnostic stimulant of growth hormone release, and its result depends on an unblunted GH response. Mecasermin is recombinant IGF-1, which exerts negative feedback on pituitary GH secretion, so it may suppress the response and cause a falsely abnormal result.
How serious is the interaction between Macimorelin and Mecasermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold mecasermin for an adequate washout period before macimorelin testing, following the macimorelin labeling, and interpret results cautiously if it was not stopped.
What other medicines interact with Mecasermin?
MediHelp also lists interactions of Mecasermin with, for example, Gliclazide, Glyburide-metformin, Insulin degludec-insulin aspart. The full list is on the Mecasermin page.
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