Drug interactions
Macimorelin + Methadone
Severity: Major
Macimorelin and Methadone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin modestly prolongs the QT interval and methadone also prolongs QT, so combined use raises the risk of torsades de pointes. The concern applies mainly around the diagnostic test dose.
What this interaction means in plain words
Macimorelin and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Methadone belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Avoid giving macimorelin to patients on methadone; consider an alternative growth hormone stimulation test. If unavoidable, check an ECG and electrolytes first.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Methadone?
MediHelp rates the interaction as major. Macimorelin and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin modestly prolongs the QT interval and methadone also prolongs QT, so combined use raises the risk of torsades de pointes. The concern applies mainly around the diagnostic test dose.
How serious is the interaction between Macimorelin and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients on methadone; consider an alternative growth hormone stimulation test. If unavoidable, check an ECG and electrolytes first.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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